Be sure to review all documentation specific to your own individual scenario before determining appropriate code assignment. This answer was provided based on limited information. Mixed autoimmune hemolytic anemia is a type of autoimmune hemolytic anemia is defined by the presence of both warm and cold autoantibodies.Įditor’s note : This question was answered by Shannon McCall, RHIA, CCS, CCS-P, CPC, CEMC, CRC, CCDS, CCDS-O, director of HIM and coding for HCPro in Middleton, Massachusetts, during the HCPro webinar, “ JustCoding's 2021 ICD-10-CM Code Updates.” In some cases, affected individuals may experience sweating and coldness of the fingers and/or toes and uneven bluish or reddish discoloration of the skin of the digits, ankles, and wrists (acrocyanosis or Raynaud’s sign). Patients with cold antibody hemolytic anemia experience weakness, dizziness, fatigue, headache, ringing in the ears (tinnitus), and spots before the eyes. In individuals with cold antibody hemolytic anemia, the red blood cells are destroyed prematurely and production rate of new cells in the bone marrow can no longer compensate for their loss. Normally, red blood cells have a life span of approximately 120 days before they are destroyed by the spleen.
Other symptoms of warm antibody hemolytic anemia include yellowing of the skin and whites of the eyes (jaundice) and enlargement of the spleen (splenomegaly).Ĭold antibody hemolytic anemia is a rare autoimmune disorder characterized by the premature destruction of red blood cells by autoantibodies at temperatures of approximately 0 to 10 degrees Celsius. It is defined by the presence of autoantibodies that destroy red blood cells at temperatures equal to or greater than normal body temperature (37 degrees Celsius).Īffected individuals may present with abnormal paleness of the skin (pallor), fatigue, and difficulty breathing upon exertion. Warm antibody hemolytic anemia is the most common form of autoimmune hemolytic anemia.
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